Cancer Prevention / News

Cutting Edge Translational Research Opportunities at the Sidney Kimmel Comprehensive Cancer Center

Elizabeth M. Jaffee, MD

Public Health Challenge

Translational research is scientific research that facilitates the translation of findings from basic science to practical applications that enhance human health and well-being.

The pancreas is the fourth most common site and cause of cancer death because it develops stealthily and progresses before diagnosis. Using pancreatic cancer as an example, the critical elements required for successful translational cancer research in the 21st Century are:

Research Findings

An important aspect of translational research is development of a concept to test in patients from prior hypotheses, pre-clinical experimentation and insightful findings. Three of these concepts under consideration in the SKCC GI Program are:

These concepts are hypothesis tested in proof of principle clinical trials, tested for efficacy and safety in clinical trials, and validated.

Future Research Directions

Identify the increasing number of regulatory pathways that require modulation to favorably tip the balance toward antitumor immunity. Gene array analysis on microdissected lymphoid aggregates are leading to improved understanding of immune signatures in the tumor microenvironment. Extend current findings into autologous mutations. Generate a preclinical animal model for testing vaccine strategies.

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